Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*
نویسندگان
چکیده
منابع مشابه
Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans
BACKGROUND Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS and sepsis-associated lung injury, the mechanisms promoting leak are incompletely understood. Angiopoietin-2 (Ang-2), a known antagonist of the endothelial Tie-2 receptor, was...
متن کاملEpidemiology of sepsis and multiple organ dysfunction syndrome in children.
STUDY OBJECTIVES To determine the cumulated incidence and the density of incidence of systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS) in critically ill children; to distinguish patients with primary from those with secondary MODS. DESIGN Prospective cohort study. SETTING Pediatric ICU of a university hospita...
متن کاملThe evolution and therapy aspects in multiple organ dysfunction sepsis
Background Severe sepsis was the subject of intense debate over the years, and in the last twenty years there has been a constant effort to identify therapies that reduce mortality. Although the inflammatory response is often adapted to the etiologic agent and to the increase of the mediators in association with organ dysfunction, it is not currently possible to rapidly assess the patients’ abi...
متن کاملAngiopoietin-2 in sepsis: lost in translation?
Iyoda et al. have provided strong experimental evidence forbeneficial effects of PDGF signalling inhibition in two see-mingly unrelated glomerular diseases: rapidly progressive glo-merulonephritis (RPGN) in the present study and focal andsegmental glomerulosclerosis (FSGS) in a previous study.Novel insights into the pathogenesis of these two diseaseshave unravelled a com...
متن کاملThe Relationship between Plasma Levels of Interleukin-6, Multiple Organ Dysfunction and Mortality in Orthopedic Patients
Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scor...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2012
ISSN: 0090-3493
DOI: 10.1097/ccm.0b013e31825fdc31